Endocrine Abstracts

Germline point mutations of the RET proto-oncogene are causative of hereditary MTC. Somatic mutations are described in 40% of sporadic MTCs. Although a relationship between somatic mutations and bad prognosis has been described, data are controversial.No date on the prognostic value of RET polymorphisms are available.Aim of the work was to verify if the presence of a somatic RET mutation and or a polymorphisms can influence the prognosis of MTC. This stu...

Introduction: In patients with primary hyperaldosteronism, distinguishing between unilateral and bilateral adrenal hypersecretion is critical in assessing treatment options. Adrenal venous sampling (AVS) has been advocated by some to be the gold standard for localization of the responsible lesion however is invasive, technically challenging, and difficult to interpret. Adrenal computed tomographic scanning (TC) is mandatory before AVS but more studies are warranted to identify...

We herein describe a 55-year-old woman who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing’s syndrome. The co-occurrence of acromegaly and Cushing’s syndrome in one individual is extremely rare. This patient was diagnosed as having diabetes mellitus 7 years ago. Afterwards, in spite of insulin therapy, her hyperglycemia could not be well controlled. Endocrinological and radiological examinations revealed sub...

BackgroundThe pathophysiology of primary polydipsia, a disorder with increased fluid intake, is poorly understood. A dysregulation in the hypothalamic-pituitary-adrenal axis (HPA) is speculated and arises mainly from research in patients witch a schizophrenia spectrum disorder but data is contradictory. The aim of this study was to investigate markers of HPA axis activity in patients with primary polydipsia compared to healthy controls.<p class="abst...

BackgroundPrimary polydipsia, characterized by excessive fluid intake, carries the risk of water intoxication and hyponatremia, but treatment options are scarce. Glucagon-like peptide-1 (GLP-1) reduces appetite and food intake. In experimental models, they also play a role in thirst and drinking behavior. The aim of this trial was to investigate whether GLP-1 receptor agonists reduce fluid intake in patients with primary polydipsia.<p class="abstext"...

Background and Aims: Diabetes is often associated with an increased severity and mortality in COVID-19 patients. Possible mechanisms include hyperglycemia-induced impaired immune response, characterized by a state of chronic low-grade inflammation. Objectives: evaluate if diabetes and glycemic control were related to the severity of disease and mortality in hospitalized COVID-19 patients.Methods: We conducted a retrospective case control study that inclu...

Objective: Currently, data about the molecular profile of multifocal papillary thyroid cancer (PTC) are still controversial. The aim of this study was to fully characterize by NGS the molecular profile of different histological variants in patients affected by multifocal PTCs.Methods: for this purpose, 12 multifocal PTC patients have been studied based to the following inclusion criteria: 1) a minimum of two tumors foci per patient with at least two diff...

Introduction: The initial clinical trials for teprotumumab excluded patients with previous orbital irradiation, surgery, glucocorticoid use (cumulative dose > 1gm), or biologic treatment. Therefore, information on the use of teprotumumab for patients who failed prior therapy is limited. Our purpose is to characterize the efficacy of teprotumumab for the treatment of recalcitrant TED.Methods: This is a multicenter retrospective study of all patients t...

Introduction: Graves Disease (GD) is an autoimmune disease, in which CD4+ Th2 cells secrete interleucin-4 (IL-4) and IL-5 and activate antibody production. IL-4 has been considered a therapeutic target for treatment of immune-related diseases, by enhancing and redirecting T and B cell function. Dupilumab, a monoclonal antibody, inhibits IL-4 and IL-13 and is currently used for treatment of atopic dermatitis, nasal polyposis and asthma. There is a single case report of painless...

About 50% of women have nausea and vomiting during pregnancy. In about 35% of women who have these symptoms, nausea and vomiting are clinically significant, worsening their living conditions and consisting in a case of gender gap. The severe form, hyperemesis gravidarum, ranges from 0.3 to 1.0% of cases and is characterized by persistent vomiting, gestational thyrotoxicosis, weight loss of more than 5%, ketonuria, hypokalemia and dehydration, although the pathophysiological me...